Dr. Rudman's Clinical Findings

In July 1990, Dr. Daniel Rudman published his landmark clinical findings on the effects of hGH in the New England Journal of Medicine. The results were exciting and startling!

Effects of hGH in men over 60 years of age

The declining activity of the growth hormone-insulin-like growth factor 1 (IGF-1) with advancing age may contribute to the decrease in lean body mass and the increase in mass of adipose tissue that occur with aging.

Trial Methods Used by Rudman

To test this hypothesis, Dr. Rudman, studied IGF-1 plasma while working with volunteers aged 61 to 81 at the Medical College of Wisconsin-Milwaukee. Dr. Rudman used hGH manufactured synthetically to replicate what is created naturally in the body's own pituitary gland.

During the treatment period, 12 men (group 1) received approximately 0.03 mg of biosynthetic human growth hormone per kilogram of body weight subcutaneously three times a week, and 9 men (group 2) received no treatment. Plasma IGF-1 levels were measured monthly. At the end of each period, Dr. Rudman's team measured lean body mass, the mass of adipose tissue, skin thickness (epidermis plus dermis), and bone density at nine skeletal sites.

Observations

Of the group who received treatment, their mean plasma IGF-1 levels rose back to youthul ranges (500-1500 U/liter), while the second group remained below (350 U/liter).

Also, in the group that received treatment for six months, it was observed that they showed an 8.8 percent increase in lean body mass, a 14.4 percent decrease in adipose-tissue mass, and a 1.6 percent increase in average lumbar vertebral bone density. Skin thickness increased .1 percent. The second group showed no significant change in lean body mass, the mass of adipose tissue, skin thickness, or bone density during treatment.

Dr. Rudman's Conclusions

Diminished secretion of growth hormone is responsible in part for the decrease of lean body mass, the expansion of adipose-tissue mass, and the thinning of the skin that occurs in old age. (New England Journal of Medicine, 1990; 323:1-6)

In middle and late adulthood, all people experience a series of progressive alterations in body composition. The lean body mass shrinks and the mass of adipose tissue expands. The contraction in lean body mass reflects atrophic processes in skeletal muscle, liver, kidney, spleen, skin, and bone.

These structural changes have been considered unavoidable results of aging. It has recently been proposed, however, that reduced availability of growth hormone in late adulthood may contribute to such changes.

These alterations in body composition caused by growth hormone deficiency can be reversed by replacement doses of the hormone, as experiments in children, and adults 20 to 50 years old have shown. These findings suggest that the atrophy of the lean body mass and its component organs and the enlargement of the mass of adipose tissue that are characteristic of the elderly result at least in part from diminished secretion of growth hormone. If so, the age-related changes in body composition should be correctable in part by the administration of human growth hormone, now readily available as a biosynthetic product.

Dr. Daniel Rudman joined the Medical College of Wisconsin, where this study was conducted, in 1988 as Professor and Associate Chief of Staff for Geriatrics and Extended Care at the Zablocki VA Medical Center. He continued his human nutrition research with the elderly until his untimely death in 1994. Dr. Rudman's life and creativity as a clinical investigator was highlighted by his ability to focus basic knowledge on important problems in clinical medicine.

Advanced Clinical hGH Studies

Since Dr. Rudman's initial findings, thousand of additional studies have supported the fact the hGH not only retards aging, but reverses the process as well.

Injectable hGH was first approved by the FDA for children suffering from dwarfism. In August 1996 the FDA approved hGH injections as anti-aging therapy with a doctors prescription. This could cost anywhere from $15,000 to $20,000 a year, and only movie stars and other wealthy individuals could obtain it and take advantage of the costly program.

Today hGH is made in the laboratory by genetic engineering methods generating an identical protein to the one made naturally in the human body. Allergic reactions are rare and it is extremely safe for adult use.

Anti-aging Health News Stories

Periodically we scan Health News from the Internet and submit them here for your reading leisure.

Female sex drive problems still a mystery

CLEVELAND, Nov. 7 (UPI) U.S. medical experts have been unable to find an approved and successful medication that will help a woman overcome a marked drop in sexual drive.

While testosterone products have been embraced overseas, related products have failed to gain approval in the United States because of arguments against their effectiveness and safety, the Cleveland Plain Dealer said Wednesday.

With such proposed medical treatments failing to gain approval from the Food and Drug Administration, women suffering from sexual dysfunction have been left with few options.

Psychiatrist Dr. Susan Rako, who wrote the book "The Hormone of Desire," has become a champion for testosterone-based products for female sexual dysfunction.

She says that stereotypes about testosterone's effects on women, along with the FDA's stance on the hormone's use for such treatments, are the key roadblocks.

"People used to think that if you gave testosterone to women, you turned them into men," she told the newspaper.

"The problem has been that the FDA has not identified testosterone deficiency as a state that needs to be treated," she added.

Source: United Press International

Polygamous men have lower testosterone

LAS VEGAS, Oct. 11 (UPI) U.S. researchers studying male herders in Kenya find men with more than one wife have lower testosterone levels than monogamously married men.

The study, published in Current Anthropology, also found monogamously married men have lower testosterone levels than single men, and married men who are considered aloof spouses and provide minimal parenting have much lower testosterone levels than single, unmarried men.

Researchers Peter Gray of the University of Nevada, Peter Ellison of Harvard University and Benjamin Campbell of Boston University, looked for links between male testosterone levels and marital status among modern-day herders in northern Kenya, known as the Ariaal.

When herd boys reach puberty, they are initiated, become warriors and accumulate livestock. They seldom marry and have children until age 30.

Less than 2 percent of the herders consider their wives a source of emotional support. Rather, they seem to value social bonds with male peers more than spousal bonds or familial bonds, the researchers said.

Source: United Press International

Lack of testosterone risk rises with age

WATERTOWN, Mass., Sept. 7 (UPI) Less than 6 percent of the male population suffer from low testosterone, however, the number rises substantially with age, a U.S. study found.

"Low levels of testosterone impact many aspects of male physiology -- such as low libido, erectile dysfunction, osteoporosis or fracture," Andre B. Araujo, of the New England Research Institutes in Watertown, Mass., said in a statement. "This is particularly significant because the ongoing aging of the U.S. male population is likely to cause the number of men suffering from androgen deficiency to increase appreciably."

The researchers analyzed data on 1,475 randomly selected men ages of 30-79 in Boston and compiled data on testosterone, symptoms of hormone deficiency and medications that may affect sex hormone levels.

The study, scheduled to be published in the November issue of the Journal of Clinical Endocrinology & Metabolism, found 5.6 percent of men in the study had symptomatic androgen deficiency but for those 70 years or older the percentage was 18.4 percent.

The study also found low testosterone levels were associated with symptoms, however, many men with low testosterone levels were asymptomatic.

Source: United Press International

Long-lasting growth hormone is developed

SHEFFIELD, England, Sept. 6 (UPI) British researchers have developed a long-acting growth hormone that reduces the need for daily therapy treatments.

Most hormones and cytokines used today have a short life, requiring frequent therapeutic injections. But the new technology developed at the University of Sheffield means scientists and clinicians will be able to generate effective, long-acting hormones that promote growth during a minimum 10-day period with one injection.

The researchers said the technology might also be used to treat inflammatory diseases such as multiple sclerosis, cancer and metabolic maladies.

However, the scientists cautioned the research is only in its early stages and any drugs resulting from the study are several years away from approval.

The research is detailed in the journal Nature Medicine.

Source: United Press International

Testosterone patch aids women's sex desire

CLEVELAND, Aug. 15 (UPI) A U.S. study of women with hypoactive sexual desire disorder, or lack of sexual interest, showed improved sexual desire following testosterone treatment.

Two randomized double-blind, placebo-controlled trials in surgically postmenopausal -- uterus and ovaries removed -- women with hypoactive sexual desire disorder showed a low-dose transdermal testosterone patch treatment resulted in significant improvements in the frequency of satisfying sexual activity and sexual desire, said the study published in the The Journal of Sexual Medicine.

Study leader Dr. Sheryl Kingsberg, of Case Western Reserve University School of Medicine, in Cleveland, conducted the two trials involving 132 participants, who were interviewed after a six-month treatment period.

The findings showed a significant increase in frequency of satisfying sexual activity and sexual desire based on women experiencing the treatment as beneficial.

Source: United Press International

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